CD33 Expression on Peripheral Blood Monocytes Predicts Efficacy of Anti-PD-1 Immunotherapy Against Non-Small Cell Lung Cancer

Non-small cell lung carcinoma (NSCLC) is the leading cause of cancer-related deaths globally.Immune checkpoint blockade (ICB) has transformed cancer medicine, with anti-programmed cell death protein 1 (anti-PD-1) therapy now well-utilized for treating NSCLC.Still, not all patients with NSCLC respond positively to anti-PD-1 therapy, and some patient

read more

In Vivo Dosimetry for Superficial High Dose Rate Brachytherapy with Optically Stimulated Luminescence Dosimeters: A Comparison Study with Metal-Oxide-Semiconductor Field-Effect Transistors

The purpose of the study was to calibrate and commission optically-stimulated luminescence dosimeters (OSLDs) for in vivo measurements in contact-based 192Ir treatments for superficial high dose rate (HDR) brachytherapy in place of metal-oxide-semiconductor field-effect transistors (MOSFETs).Dose linearity and dose rate dependence were tested by va

read more

Water Flow in Soils with Heterogeneous Macropore Geometries

Heterogeneous macroporous geometries (HMGs) comprise unevenly distributed macropores with depth.A large variety of macropore distributions produce fast water flow and chemical transport that deviate from uniform flow.We analyzed the measured pressure head and outflow in column experiments with a uniform matrix (Exp.I), one central macropore (main b

read more